For those who are familiar with organic chemistry, you will find the link to the original article below. Hope you enjoy reading it!
Synergistic Diastereo- and Enantioselective Functionalization of Unactivated Alkyl Quinolines with α,β-Unsaturated Aldehydes
Dr. Marta Meazza, Dr. Fernando Tur, Niels Hammer and Prof. Dr. Karl Anker Jørgensen
A fruitful partnership: InCl3 activation of unactivated alkyl quinolines has been combined with organocatalytic activation of α,β-unsaturated aldehydes. The reaction involves two consecutive synergistic catalytic cycles and provides selectively double- or mono-addition products in good yields and high to excellent stereoselectivities. Based on spectroscopic and labeling experiments, the reaction mechanisms are discussed.